Long-term antibiotic acne treatment unlikely to cause bacterial resistance
The researchers carried out a cross-sectional survey of 83 acne patients with a mean age of 25.6 years, who visited a dermatology outpatient clinic. All participants filled out a comprehensive survey, underwent a visual examination for acne presence and severity, and had swabs taken from their nose and throat to test for S. aureus.
When patients with acne who were antibiotic users (n=52; oral and/or topical) were compared with nonusers (n=31), the risk for S. aureus colonization after 1-2 months of treatment was reduced by 84%. After 2 months, the reduction in risk for colonization was 48% lower in antibiotic users compared with nonusers.
Although 40% and 44% of the S. aureus isolates (obtained from 36 participants in total) were resistant to clindamycin and erythromycin, respectively, less than 10% showed resistance to tetracycline antibiotics, which, the researchers say are the most commonly used antibiotics to treat acne.