簡言之,這三樣加起來可能藉由抑制5 alpha還原酶來增加毛髮生長,但還僅限於體外實驗,自1988年到現在,都還沒有人體內實驗持續支持這項假設。
 
Br J Dermatol. 1988 Nov;119(5):627-32.

Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid.

Author information 

  • 1Laboratoire de Biochimie B, Hôpital Necker-Enfants-Malades, Paris, France.

Abstract

The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.

 

 

本站文章版權所有,歡迎非商業性『部份』轉載(請勿全文轉載),轉載請註明作者姓名標示與出處,禁止更動內文,並提供有效的該篇文章超連結。

 

 

延伸閱讀

含矽靈的洗髮精到底安不安全?

http://yanjiskin.pixnet.net/blog/post/420444223

 

養髮產品常使用的『藍銅胜肽』是什麼?

http://yanjiskin.pixnet.net/blog/post/229206419

 

古老的神秘配方染髮-- 指甲花

http://yanjiskin.pixnet.net/blog/post/229200485

 

 

 

arrow
arrow
    全站熱搜

    皮膚科劉權毅醫師 發表在 痞客邦 留言(0) 人氣()