皮膚科 劉權毅醫師

中時電子報 2011/07/19 【中時健康 黃曼瑩／台北報導】
愛美要小心謹慎！近年臨床上發現有一些醫美手術失敗的案例，有人使用雷射溶脂企圖想要甩掉蝴蝶袖或腿部肥滋滋的脂肪，因為操作不慎，雷射能量過大竟然燒壞神經與血管，導致手臂抬不起來，甚至腿部無法行走的後遺症，令人聞之色變！愛美如果承受過大安全風險，無疑是一條不歸路。還好目前通過美國FDA認証許可安全無副作用的「冷凍溶脂」身材雕塑方式已經問市，尤其是針對「小腹婆」或有「水桶腰」的人來說，可在兩個月可消除約22%贅肉，成為一項新選擇。

原文
http://dermatology.cdlib.org/143/commentary/alopecia/scheinfeld.html

dermal melanocytoses可分成
1. classic Nevus of Ota

http://www.dermquest.com/expert_opinions/surgery__cosmetics/botulinum_toxin_around_the_mouth.html

http://www.dermquest.com/expert_opinions/clinical_updates/facial_dermal_melanocytosis_common_misdiagnoses_.html
Dermal melanocytoses are usually localized and are especially common in Asians. Clinically, they all share a bluish-gray coloration. When a sufficient number of melanin-containing cells are present in the dermis, various clinical forms develop depending on their onset and distribution. Although most dermal melanocytoses are congenital or have an onset in early childhood, there is a group that is clearly acquired, with an onset in adult life. Mongolian spots typically disappear in childhood, whereas other dermal melanocytoses persist for life.

上一篇文章提到了基本防曬概念，以下接著來談門診病人常問的進階問題：

最近很榮幸的受邀在警廣的『健康你我他』(2011/7/4)節目中談到如何做好夏日防曬，
短短二十分鐘很難把所有的防曬概念教給大家，

更新日期:2011/07/05 04:11
青春痘並不是青少年的專利，有許多成年人也有青春痘的困擾。那是因為青春痘除了和皮脂腺分泌有關外，荷爾蒙、壓力、不正常的生活作息、藥物等，都會導致青春痘的產生。此外，常有門診病患反映，吃到某些特定的食物，例如油炸類或是巧克力，會冒更多的痘痘。

I. Congenital
Hartnup disease

Certolizumab pegol is a monoclonal antibody directed against tumor necrosis factor alpha. More precisely, it is a PEGylated Fab' fragment of a humanized TNF inhibitor monoclonal antibody

November 24, 2009 (San Diego, California) — A new fully human monoclonal antibody (MAb) against TNF, golimumab (CNTO148, Centocor/Schering-Plough), is close to entering the market. Results from a phase2 clinical trial of 172 patients with rheumatoid arthritis (RA) show encouraging safety and efficacy data, investigators reported at the 2005 ACR/ARHP Annual Scientific Meeting [ 1 ]. Phase 3 studies of RA, psoriatic arthritis, and ankylosing spondylitis are planned to start soon, the companies tell rheuma wire . Golimumab could be launched in 2007.
 

Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease characterized by the predominant infiltration of TH2-type cells in lesional skin. Thymus and activation-regulated chemokine (TARC/CCL17) is a chemokine that attracts CC chemokine receptor 4–positive (CCR4+) or CCR8+ cells. Objective: The purpose of this study was to investigate the participation of TARC in AD. Methods: We measured serum TARC levels in 40 patients with AD, 20 healthy control subjects, and 20 patients with psoriasis. We also examined disease activity by using SCORAD score; serum soluble E-selectin, soluble IL-2 receptor, IgE, and GM-CSF levels; and eosinophil numbers in peripheral blood, as well as correlations between TARC levels and these factors. The positivity of CCR4 of CD4+CD45RO+ cells in PBMCs was examined by using FACS analysis. Immunohistochemical staining of TARC and GM-CSF was performed in the lesional skin of patients with AD. Results: The serum TARC levels of patients with AD were significantly higher than those of healthy control subjects and patients with psoriasis. The serum TARC levels significantly correlated with eosinophil number (r = 0.61), SCORAD score (r = 0.60), and serum soluble E-selectin levels (r = 0.58) and weakly correlated with serum soluble IL-2 receptor levels (r = 0.34) in patients with AD. The TARC levels of patients with AD decreased after the treatment in accordance with the improvement of clinical symptoms. The CCR4 positivity of CD4+CD45RO+ cells in PBMCs of patients with AD was also higher than that of healthy control subjects. Immunohistochemical staining revealed that TARC was positive in ke-ratinocytes in the epidermis and in vascular endothelial cells, T cells, and dendritic cells in the dermis. Conclusion: Serum TARC levels are associated with disease activity of AD, and TARC may play an important role in the pathogenesis of AD. (J Allergy Clin Immunol 2001;107:535-41.)

SCORAD is a clinical tool used to assess the extent and severity of eczema (SCORing Atopic Dermatitis). Dermatologists may use this tool before and after treatment to determine whether the treatment has been effective.

Area

To determine extent, the sites affected by eczema are shaded on a drawing of a body. The rule of 9 is used to calculate the affected area (A) as a percentage of the whole body.

中央廣播電台:2011/06/07
根據6日發表的一項統合分析報告，帕金森氏症(Parkinson's disease)患者所面臨的致命皮膚癌--黑色素瘤風險，為常人的2倍。

最近「百萬小學堂」出了一題有趣的問題，並找了我幫製作單位審題。
據說節目已經播出，所以題目可以公布了，題目如下: